Table 2.
Baseline Biomarker Levels and Risk of All-Cause Mortality for Cases and Matched Controls
| |
Cases |
Controls |
Unadjusteda |
Adjustedb |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sampling point/biomarker | Median (25th, 75th %ile) | Median (25th, 75th %ile) | OR | 95% CI | p-value | AOR | 95% CI | p-value | ||
| Baseline | ||||||||||
| IL-6 (pg/ml) | 4.37 (2.76, 8.16) | 2.34 (1.39, 4.14) | 1.30 | 1.09 | 1.54 | <0.001 | 1.25 | 1.05 | 1.48 | 0.012 |
| hsCRP (μg/ml) | 8.38 (3.02, 20.06) | 2.34 (0.88, 5.9) | 1.17 | 1.01 | 1.35 | 0.04 | 1.14 | 0.97 | 1.35 | 0.123 |
| D-dimer (μg/ml) | 0.87 (0.52, 1.68) | 0.59 (0.46, 0.93) | 1.48 | 0.94 | 2.34 | 0.09 | 1.35 | 0.77 | 2.36 | 0.293 |
| Latest level | ||||||||||
| IL-6 (pg/ml) | 5.01 (2.04, 9.93) | 1.46 (0.84, 2.38) | 1.58 | 1.16 | 2.14 | <0.001 | 1.48 | 1.05 | 2.09 | 0.027 |
| hsCRP (μg/ml) | 24.26 (4.44, 86.74) | 3.55 (1.66, 9.63) | 1.04 | 1.00 | 1.09 | 0.04 | 1.02 | 0.95 | 1.09 | 0.573 |
| D-dimer (μg/ml) | 0.67 (0.40, 1.77) | 0.45 (0.33, 0.73) | 1.09 | 0.89 | 1.33 | 0.41 | 1.42 | 0.66 | 3.04 | 0.366 |
a
p-values obtained from a univariate conditional logistic model.
b
p-values obtained from a conditional logistic model with adjustments for baseline BMI and OIs.
OR, odds ratio; CI, confidence interval; AOR, adjusted odds ratio; IL-6, interleukin-6; hsCRP, high-sensitivity C-reactive protein; OIs, opportunistic infections.