Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure and IC50 values of select chelating 2-sulfonamidophenylbenzimidazole (BIS1, left) and 8-sulfonamidoquinoline (QS1, middle) inhibitors. The BIS1 inhibitor displays better overall selectivity for MMP-2 versus other MMPs. The proposed mode of binding for these chelating sulfonamide inhibitors is shown on the right.
