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HIV downmodulates NETosis via dendritic cells. HIV triggers NETosis via a process that involves TLR7 and TLR8, trapping individual HIV virions in the NET lattice. Viral binding to CD209 anchors the virions on dendritic cells (DC), thereby promoting the efficient infection of CD4+ T cells. The gp120/CD209-primed DC cells produce the immune-modulating cytokine IL-10, leading to a reduction in NETotic capability, thereby preventing PMN from effectively engaging and eliminating HIV
