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. Author manuscript; available in PMC: 2013 Jun 19.
Published in final edited form as: Integr Biol (Camb). 2011 Mar 24;3(5):578–591. doi: 10.1039/c0ib00141d

Fig. 1.

Fig. 1

Overview of BLR1-MAPK positive feedback loop driving RA induced HL-60 arrest and differentiation. RA signals are intercepted by a family of RAR/RXR nuclear receptors which in turn drive the expression of genes with RARE promoter elements. One key RA-regulated protein is BLR1. BLR1, a putative G protein-coupled transmembrane surface receptor, drives an atypical sustained MAPK signal which in turn activates the expression of genes required for the execution of the cell-cycle arrest and differentiation programs. MAPK also activates factors in the BLR1 transcriptional activator complex resulting in positive feedback.