Table 1.
Transcription factors (TFs), corresponding kinases and transcription factor target genes used in the transcription subnetwork.
| TF | Kinase | Targets | Citation |
|---|---|---|---|
| ETS | ERK | IRF | 93,108 |
| SRPK2 | |||
| p47Phox | |||
| CD45 | |||
| EIF2AK | |||
| SIIIp15 | |||
| BRN | — | IRF | 93 |
| SRPK2 | |||
| RhoGDI | |||
| p47Phox | |||
| CD45 | |||
| EIF2AK | |||
| SIIIp15 | |||
| CREB | PKCα | IRF | 21,93‡ |
| SRPK2 | |||
| RhoGDI | |||
| p47Phox | |||
| CD45 | |||
| EIF2AK | |||
| SIIIp15 | |||
| BLR1* | |||
| Oct1 | — | IRF | 21,93 |
| SRPK2 | |||
| RhoGDI | |||
| p47Phox | |||
| CD45 | |||
| EIF2AK | |||
| SIIIp15 | |||
| BLR1* | |||
| NFATc3 | ERK | BLR1* | 77 |
| E2F | — | CycE, E2F | 109 |
| AP1 | ERK | CycD | 108 |
*
TFs for BLR1 interact with each other to promote BLR1 transcription (AND relationship). Alternatively, the other TFs in the model were assumed to independently drive gene expression of their target genes (OR relationship).
‡
Interaction determined via NetworKIN.57