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Predicted and measured RA-induced protein expression shifts at 3, 12 and 24 h after the addition of 1 μM RA to exponentially growing HL-60 cells. Plus (+) indicates that the model and experiment agreed on the statistically significant direction of the shift (up, down or no change). Minus (−) indicates no match. The data was reproduced from Yen and coworkers.93
| Protein | 3 h | 12 h | 24 h |
|---|---|---|---|
| p47Phox | + | + | + |
| SPRK2 | + | + | + |
| PRK | + | + | − |
| RhoGDI | + | − | − |
| Cyclin D | − | + | − |
| CD45 | + | − | − |
| IRF | − | − | − |
