Figure 7.

Genetic mutation of Clock disrupts p75^NTR expression in the SCN and liver. Wild-type mice and Clock^Δ19 mice were entrained in a 12 h light/dark cycle and killed at 6 h intervals (n = 3 per group and genotype). At the indicated times, SCN (left) and liver (right) were dissected; RNA was extracted; and p75^NTR, Per1, Rev-Erbα, and Dbp levels were analyzed by real-time PCR. Data from CT21 are double plotted. Error bars represent the SEM of the mean, where the maximum RNA amount was set to 100. CT, Circadian time.