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. 2013 Jun 19;33(25):10405–10426. doi: 10.1523/JNEUROSCI.0014-13.2013

Figure 2.

Figure 2.

Repeated amphetamine produces PPP. A, Representative traces (top) show the average responses of cortically evoked paired pulses in MSNs before (left) and 5 min after bath application of amphetamine (right). Graph shows the normalized amplitude of the first eEPSC (of the pair) and the normalized PPR. In saline-exposed mice, amphetamine in vitro decreased the amplitude of the first eEPSC and increased the PPR. Ten days (B) and 21 d (C) after repeated amphetamine in vivo, bath-applied amphetamine increased the eEPSC amplitude and decreased the PPR. D, Representative traces (top) show mEPSCs in MSNs from saline-exposed mice in aCSF (left) and 5 min after bath-applied amphetamine (right). Amphetamine in vitro decreased the frequency of mEPSCs (inset, left) primarily by inhibiting small amplitude (5–10 pA) spontaneous inward currents while having no effect on their cumulative amplitude distribution (inset, right). For D--F: *p < 0.05, **p < 0.01, paired t test. E, On WD 10 and F, WD 21 after repeated amphetamine, bath-applied amphetamine increased the frequency of mEPSCs (inset, left) by boosting the high-frequency, low-amplitude spontaneous inward currents while having no effect on their cumulative amplitude distribution (inset, right). Scale bars in A–C, 100 pA, 5 ms; D--F, 10 pA, 1 s.