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. 2013 Jun 19;33(25):10405–10426. doi: 10.1523/JNEUROSCI.0014-13.2013

Figure 3.

Figure 3.

D2Rs remain inhibitory after repeated amphetamine. A, Representative traces (top) show average responses to cortically evoked paired pulses in MSNs before (left) and 5 min after bath application of the D2R agonist quinpirole (right). In both saline-exposed (A) and amphetamine-exposed (B) mice, bath-applied quinpirole decreased the amplitude of the first eEPSC and increased the PPR. C, Representative traces (top) show mEPSCs in aCSF (left) and 5 min after bath-applied quinpirole (right). In both saline-exposed (C) and amphetamine-exposed (D) mice, quinpirole decreased the frequency of mEPSCs (inset, left) by inhibiting the number of high-frequency, low-amplitude spontaneous inward currents while having no effect on their cumulative amplitude distribution (inset, right). For C and D, *p < 0.05, **p < 0.01, paired t test. Scale bars in A, B, 100 pA, 5 ms; C, D, 10 pA, 1 s.