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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2013 Apr 22;21(13):3702–3707. doi: 10.1016/j.bmc.2013.04.027

Scheme 1.

Scheme 1

synthesis of artemisinin dimer phosphates, reagents and conditions: (a) (i) DIBALH, CH2Cl2, −78 °C; (ii) DMAP, py, Ac2O, −78 °C to rt, 95%; (b) SnCl4, CH2Cl2, −78 °C, 85%; (c) (i) BH3:SMe2, THF, 0 °C; (ii) NaBO3:4H2O, 0 °C to rt, 85%; (d) diphenylphosphoryl chloride 10, DMAP, py, CH2Cl2, rt, 95%; (e) NaOH, DMF, 50 °C, 56%.