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. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Bioorg Med Chem. 2013 Apr 22;21(13):3702–3707. doi: 10.1016/j.bmc.2013.04.027

Scheme 2 — synthesis of phosphoryl chlorides, reagents and conditions: (a) AlCl₃, PXCl₃, 150 °C, microwave, 1 h 62–93% crude; (b) (i) NaH, THF, rt to 50 °C; (ii) PCl₃; (c) dimethylimidazolinone, triphosgene, CH₂Cl₂, 85% over two steps.

Scheme 2 — synthesis of phosphoryl chlorides, reagents and conditions: (a) AlCl₃, PXCl₃, 150 °C, microwave, 1 h 62–93% crude; (b) (i) NaH, THF, rt to 50 °C; (ii) PCl₃; (c) dimethylimidazolinone, triphosgene, CH₂Cl₂, 85% over two steps.