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Biological and therapeutic actions of H2S are O2-dependent.
| Biological context | Low O2 | High O2 |
|---|---|---|
| Inflammation | Anti-inflammatory: IL-10; ↓ IL-6, ICAM | Pro-inflammatory: ↑ NF-κB, TNF-α |
| Vasoactivity | Vasodilatory: ↑ KATP channel conductance | Vasoconstrictive |
| Angiogenesis | Pro-angiogenic: VEGF, Hif1-α | No effect |
| Respiratory inhibition | Higher [H2S] results in more inhibition | O2 acts as an H2S antagonist: ↑SOx |
| Ischemia-reperfusion | Ischemic tissue has higher [H2S]: mito KATP, ARE genes | Unknown |
