Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Mar 26;269(2):100–108. doi: 10.1016/j.taap.2013.03.012

Figure 2. Monohydroxylated metabolites of JWH-018 retain nanomolar CB2R affinity.

Figure 2

A measure of CB2R affinity (Ki) for JWH-018 and respective metabolites, was obtained by evaluating competition binding between increasing concentrations of each test compound and the radiolabeled cannabinoid [3H]CP-55,940 in CHO-hCB2 membranes [A]. Ki values (mean ± SEM) are provided in Table 1 [B].

*Significantly different from the Ki value determined for Δ9-THC (P<0.05; ANOVA + Dunnett’s post-hoc comparison).