Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Mar 26;269(2):100–108. doi: 10.1016/j.taap.2013.03.012

Figure 6. The omega hydroxyl metabolite (M5) of JWH-073 produces equipotent AC-inhibition compared with its parent, despite having 10-fold lower affinity for CB2Rs.

Figure 6

The affinity (Ki) of cannabinoids for CB2Rs [A], [C] and [E] determined by receptor binding, were compared with the respective potency (IC50) for inhibition of AC-activity [B], [D] and [F] in CHO-hCB2 cells. All Ki and IC50 values (mean ± SEM) were derived from non-linear regression analysis of the curves presented and specific values are provided in Table 1.