Table 2.
Maximal Efficacy of JWH-018 and JWH-073 metabolites for regulation of G-protein and AC-activity via CB2Rs
| Drug | CB2R Efficacy (EMAX) | ||
|---|---|---|---|
| G-protein Activation (fmole/mg) |
AC-Inhibition (% Inhibition) |
||
| CP-55,940 | 96.1 ± 1.6 (13) | 67.3 ± 3.5 (6) | |
| Δ9-THC | N.D. | 49.2 ± 1.4 (5) | |
| JWH-018 | 60.3 ± 11.4 (7) | 59.3 ± 4.0 (4) | |
| M1 | 48.0 ± 11.3 (5) | 46.9 ± 3.2 (4) | |
| M2 | 38.0 ± 10.4 (6) | 55.1 ± 2.7 (4) | |
| M3 | 79.7 ± 20.4 (6) | 57.7 ± 1.4 (4) | |
| M5 | 38.4 ± 8.5 (5) | 53.5 ± 4.6 (4) | |
| M6 | N.D. | N.D. | |
| M7 | 15.0 ± 4.7 (4) | 62.7 ± 2.5 (5) | |
| JWH-073 | 40.1 ± 4.2 (3) | 62.6 ± 2.7 (3) | |
| M1 | 20.3 ± 3.0 (3) | 49.1 ± 3.8 (4) | |
| M2 | 17.6 ± 5.7 (4) | 55.8 ± 4.9 (4) | |
| M3 | 48.5 ± 3.8 (3) | 56.8 ± 5.7 (4) | |
| M5 | 31.0 ± 1.0 (3) | 54.2 ± 5.9 (4) | |
| M6 | N.D. | N.D. | |
| M7 | 48.2 ± 10.9 (3) | 54.4 ± 6.2 (6) | |
The data are presented as the mean ± SEM (number of replications)
N.D. = Not determined