Figure 4.
MET mutations identified in human cancers. Color coding of the mutation symbols above and below the MET protein diagram identifies the type of human tumor: black, papillary renal cell carcinoma; red, hepatocellular carcinoma; green, glioma; blue, lung carcinoma; purple, gastric carcinoma; orange, cancer unknown primary origin (CUP). Genetic alterations were found in the following tumors: L964_D1010del, lung adenocarcinoma; A1108S, squamous lung carcinoma; E168D, small cell lung carcinoma; intron 13 insertion 9IVS13-(52-52)insCT, small cell lung carcinoma; T1010I, small cell lung carcinoma. Note that T1010I was also found in a breast carcinoma and CUP; E168D was found in a CUP; Y1235D and Y1230C/D were identified in head and neck squamous cell carcinomas, respectively.