Table 2.
Effects of Spirogyra neglecta extract on general characteristics of T2DM experimental rats.
| ND | ND + SNE1.0 | DM | DM + SNE0.25 | DM + SNE0.5 | DM + SNE1.0 | DM + vitamin C | |
|---|---|---|---|---|---|---|---|
| General characteristic | |||||||
| BW (g) | 516.0 ± 57.3 | 493.3 ± 40.3 | 500.0 ± 48.6 | 510.0 ± 54.5 | 515.5 ± 49.6 | 520.0 ± 49.7 | 525.0 ± 19.1 |
| KW/BW ratio | 4.7 ± 0.5 | 4.9 ± 0.3 | 5.0 ± 1.1 | 4.8 ± 0.7 | 5.0 ± 0.3 | 4.3 ± 0.9 | 6.3 ± 1.9 |
|
| |||||||
| Plasma parameters | |||||||
| Glucose (mg/dL) | 131.0 ± 20.3 | 124.8 ± 18.3 | 305.0 ± 58.1* | 244.4 ± 58.6* | 198.0 ± 14.1# | 125.6 ± 24.6# | 277.5 ± 62.5* |
| Triglyceride (mmol/L) | 124.7 ± 11.5 | 101.6 ± 23.5 | 266.5 ± 59.3* | 229.5 ± 17.5* | 145.6 ± 48.2# | 156.9 ± 34.5# | 153.5 ± 18.6# |
| Insulin (ng/mL) | 2.2 ± 0.5 | 2.0 ± 0.8 | 1.7 ± 0.5 | 1.6 ± 0.1 | 2.3 ± 1.0 | 1.0 ± 0.4 | 1.0 ± 0.6 |
| HOMA index | 17.9 ± 4.9 | 16.0 ± 8.2 | 31.6 ± 11.4* | 28.8 ± 1.9* | 16.2 ± 6.1# | 15.1 ± 7.9# | 38.4 ± 20.1* |
Data are presented as mean ± S.E.M. from 6 animals per group. BW: body weight, KW: kidney weight, HOMA: homeostatic model assessment of insulin resistance, *P < 0.05 indicates the significant differences from normal (ND), and # P < 0.05 indicates the significant differences from T2DM rats.