Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2014 May 8.

Published in final edited form as: J Am Chem Soc. 2013 Apr 29;135(18):6860–6871. doi: 10.1021/ja311963f

(A,B) Negatively stained TEM images of "quiescent" and "agitated" Aβ_1–40 fibrils (called and fibrils), showing their distinct morphologies. These fibrils resulted from seeded growth at 24° C, using 50 µM initial monomer concentrations. (C,D) Representative AFM images of fibrils from elongation measurements after 0 and 20 min incubation, respectively. Measurements were done at 24° C with 50 µM soluble Aβ_1–40 concentration. (E,F) Representative AFM images of fibrils from shrinkage measurements at 24° C after 2 hr and 46 hr incubation, respectively. Vertical scales represent AFM feedback error signals, not height.

Inline graphic — (A,B) Negatively stained TEM images of "quiescent" and "agitated" Aβ_1–40 fibrils (called and fibrils), showing their distinct morphologies. These fibrils resulted from seeded growth at 24° C, using 50 µM initial monomer concentrations. (C,D) Representative AFM images of fibrils from elongation measurements after 0 and 20 min incubation, respectively. Measurements were done at 24° C with 50 µM soluble Aβ_1–40 concentration. (E,F) Representative AFM images of fibrils from shrinkage measurements at 24° C after 2 hr and 46 hr incubation, respectively. Vertical scales represent AFM feedback error signals, not height.