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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Biol Psychiatry. 2013 Feb 23;73(9):877–886. doi: 10.1016/j.biopsych.2013.01.014

Table 2.

Group Differences During MIDT

MIDT
Phase		 Structure BA Left/
Right		 MNI
Coordinates
 k T
Value
x y z
OB vs. LC
  A1Win Insula/Inferior Parietal Lobule/Superior Temporal Gyrus 13 L −54 −36 −24 152 −3.88
Precentral Gyrus 4 R 45 −6 60 424 −3.77
Cerebellum/Uvula — L −3 −69 −39 121 −3.67
Precentral Gyrus/Insula/Postcentral Gyrus/Superior Temporal Gyrus 6 L −39 −15 33 497 −3.53
Lingual Gyrus/Culmen/Declive 18 R 9 −72 −3 228 −3.38
Middle Temporal Gyrus 19 L −51 −81 21 133 −3.29
Cingulate Gyrusa 24 L −3 −9 51 110 −3.02
  A1Loss Middle Frontal Gyrus/OFC 11 R 27 42 −21 108 −3.87
Parahippocampal Gyrus/Fusiform Gyrus 20 L −39 −18 −27 105 −4.09
Postcentral Gyrus/Insula 13 R 54 −12 21 111 −4.05
Culmen/Declive/Fusiform Gyrus — L −18 −51 −27 237 −3.83
Inferior Parietal Lobule/Superior Temporal Gyrus/Insula 40 L −57 −42 21 118 −3.64
Declive/Culmen/Lingual Gyrus — L 0 −72 −18 305 −3.44
Medial Frontal Gyrus/Paracentral Lobule/Cingulate Gyrus 6 L −6 0 54 131 −3.36
Precentral Gyrus/Postcentral Gyrus 4 L −39 −15 36 197 −3.33
  A2Win Inferior Frontal Gyrus/OFC 11 R 21 33 −24 113 3.79
Inferior Frontal Gyrus/Middle Frontal Gyrus/Claustrum 46 L −42 30 12 105 3.74
Cingulate Gyrus/Caudate 31 L −18 −21 42 133 3.59
Thalamus/Cingulate Gyrus/Hypothalamus/Caudate/Lentiform Nucleus/Ventral Striatum — R 9 −3 −3 195 3.54
Cingulate Gyrus/Superior Parietal Lobulea 31 L −24 −42 21 114 3.07
  A2Loss Inferior Frontal Gyrus/vmPFC/OFC/Ventral Striatum 11 L −24 33 −27 181 4.33
Middle Frontal Gyrus/OFC 11 R 24 45 −15 131 3.66
Medial Frontal Gyrus/Middle Frontal Gyrus/Inferior Frontal Gyrus/Anterior Cingulatea 9 R 15 36 21 124 3.06
Culmen/Midbrain Substantia Nigra/Red Nucleusa — R 12 −33 −24 91 2.92
  OCWin Middle Temporal Gyrus/Superior Occipital Gyrus/Cuneus 19 L −48 −84 24 95 −3.51
Precentral Gyrus/Middle Frontal Gyrus/Postcentral Gyrus 4 L −33 −15 51 148 −3.27
Precuneus/Posterior Cingulate 23 L 0 −57 21 101 −3.21
  OCLoss Precuneus/Posterior Cingulate 23 L 0 −60 21 196 −4.15
Middle Temporal Gyrus/Precuneus 19 L −51 −81 21 158 −3.96
Middle Temporal Gyrus/Superior Occipital Gyrus/Precuneus 39 R −27 −9 60 217 −3.64
Precentral Gyrus/Medial Frontal Gyrus/Postcentral Gyrus 6 L −27 −9 60 351 −3.58
BED vs. LC
  A1Win — — — — — — — —
  A1 Loss Inferior Frontal Gyrusa 45 R 45 30 9 106 3.03
Middle Occipital Gyrus 18 L −30 −99 12 115 −3.30
  A2Win Caudate/Middle Frontal Gyrus/Claustrum/Inferior Frontal Gyrus 46 R 9 6 24 226 3.99
Cingulate Gyrus/Caudate 24 L −18 −18 39 257 3.87
Caudate/Superior Temporal Gyrus — R 33 −45 9 287 3.56
Cuneus/Lingual Gyrus 19 L −9 −93 33 174 −4.27
Medial Frontal Gyrus 6 R 3 0 63 108 −4.21
  A2Loss Caudate/Inferior Frontal Gyrus — R 24 24 21 161 3.71
Superior Occipital Gyrus/Cuneus 19 R 39 −87 30 133 −3.99
Cuneus/Middle Occipital Gyrus/Middle Temporal Gyrus/Lingual Gyrus 18 L −12 −72 12 520 −3.73
Fusiform Gyrus/Posterior Cingulate/Culmen 37 R 36 −54 −15 217 −3.47
  OCWin Middle Temporal Gyrus/Inferior Occipital Gyrus 37 L −39 −57 −9 255 3.39
Superior Temporal Gyrus/Precuneus/Insula/Precentral Gyrus/Cingulate Gyrus/Posterior
CingulateLingual Gyrus/Supramarginal Gyrus		 22 R 63 −30 24 1648 −5.35
Inferior Parietal Lobule/Insula/Posterior Cingulate/Superior Temporal Gyrus/Cuneus/Precentral 40 L −69 −33 30 3606 −4.95
Gyrus/Ventral Striatum/Caudate/Precuneus/Postcentral Gyrus/Cingulate Gyrus
Anterior Cingulate/Inferior Frontal Gyrus/Caudate		 24 L 0 21 24 271 −3.93
Medial Frontal Gyrus 10 L −6 54 12 144 −3.52
Ventral Striatum/Lentiform Nucleus R 21 3 −12 105 −3.41
  OCLoss Inferior Occipital Gyrus/Middle Occipital Gyrus/Lingual Gyrus/Middle Temporal Gyrus 18 L −33 −90 −9 406 3.93
Middle Occipital Gyrus 18 R 27 −84 −12 113 3.56
Precentral Gyrus/Cingulate Gyrus/Anterior Cingulate/Paracentral Lobule 4 L −21 −21 54 581 −4.54
Superior Temporal Gyrus/Transverse Temporal Gyrus/Postcentral Gyrus/Insula 13 R 54 −36 21 624 −4.46
Insula/Precentral Gyrus/Inferior Parietal Lobule/Postcentral Gyrus 13 L −42 −6 0 547 −4.42
Posterior Cingulate/Precuneus/Lingual Gyrus/Cuneus 30 L −24 −57 9 791 −4.35
Angular Gyrus 39 L −48 −75 36 178 −3.77
Thalamus/Midbrain/Culmen — R 15 −27 −15 107 −3.66
BED vs. OB
  A1Win Inferior Frontal Gyrus/Insula 13 L −42 12 15 121 4.10
Middle Frontal Gyrus/Caudate/Putamen/Claustrum 46 R 39 21 15 162 3.60
Precentral Gyrus/Postcentral Gyrus 31 R 39 −12 45 99 3.36
Lingual Gyrus/Fusiform Gyrusa 18 R 3 −84 −12 243 3.02
  A1Loss Inferior Frontal Gyrus/Insula 44 L −45 27 −3 128 3.94
Fusiform Gyrus/Lingual Gyrus 19 R 30 −81 −15 108 3.24
  A2Win Posterior Cingulate/Middle Occipital Gyrus/Culmen/Cuneus/Lingual Gyrus/Declive 30 L −18 −66 3 1339 −4.95
Lentiform Nucleus/Hypothalamus/Thalamus/Caudate/Culmen/Claustrum/Midbrain Red Nucleus/ Parahippocampal Gyrus/Putamen/Ventral Striatum/vmPFC/Insula — R 27 12 −3 1475 −4.52
Superior Occipital Gyrus/Precuneus/Inferior Parietal Lobule 19 R 48 −78 33 129 −4.24
Middle Occipital Gyrus/Inferior Parietal Lobule/Supramarginal Gyrus/Middle Temporal Gyrus/
Superior Temporal Gyrus		 18 R 33 −96 6 481 −4.19
Cingulate Gyrus/Medial Frontal Gyrus/Superior Frontal Gyrus 31 R 15 −21 48 386 −3.98
Insula/Superior Temporal Gyrus 13 R 45 −30 18 135 −3.97
Inferior Parietal Lobule/Precuneus/Angular Gyrus 40 L −33 −54 51 192 −3.63
Precentral Gyrus/Inferior Frontal Gyrus 6 L −60 3 30 97 −3.57
Precentral Gyrus 4 L −42 −12 63 92 −3.42
Fusiform Gyrus/Culmen/Uvula/Declive 37 R 45 −51 −15 205 −3.27
  A2Loss Lingual Gyrus/Posterior Cingulate/Cuneus/Declive/Middle Temporal Gyrus/Culmen/
Parahippocampal Gyrus		 18 L −15 −69 −6 1161 −4.88
Midbrain Red Nucleus/Thalamus/Lentiform Nucleus/Ventral Striatum/Caudate/Putamen/Midbrain
Substantia Nigra/OFC		 — R 3 −15 −21 828 −4.82
Inferior Parietal Lobule/Middle Occipital Gyrus/Cuneus/Precuneus/Superior Parietal Lobule 40 R 39 −48 54 532 −4.55
Superior Temporal Gyrus/Middle Temporal Gyrus/Insula/Fusiform Gyrus 41 R 51 −30 12 313 −4.01
Inferior Parietal Lobule/Precuneus 40 L −36 −54 48 205 −3.98
Superior Frontal Gyrus/Inferior Frontal Gyrus/vmPFC/Anterior Cingulate/OFC 11 R 12 51 −24 143 −3.85
Precentral Gyrus 6 L −63 6 21 99 −3.81
Cingulate Gyrus/Medial Frontal Gyrus 31 R 9 −9 51 96 −3.63
Middle Occipital Gyrus/Cuneus 18 L −33 −96 0 178 −3.52
Precentral Gyrus/Postcentral Gyrus/Inferior Parietal Lobule 6 L −45 −3 57 183 −3.51
  OCWin Precuneus/Lingual Gyrus/Caudate/Insula/Inferior Parietal Lobule/Middle Temporal Gyrus/Superior 31 L −24 −72 15 2307 −4.98
Temporal Gyrus/Parahippocampal Gyrus/Medial Frontal Gyrus/Cuneus/Inferior Frontal Gyrus/
Lentiform Nucleus/Ventral Striatum/Putamen/Caudate/Superior Temporal Gyrus/Claustrum/
Thalamus/Posterior Cingulate/Anterior Cingulate/Middle Frontal Gyrus/OFC/Cingulate Gyrus/
Hypothalamus/Inferior Frontal Gyrus
Insula/Superior Temporal Gyrus/Precentral Gyrus/Inferior Parietal Lobule/Inferior Frontal Gyrus/
Caudate		 13 R 45 12 −6 605 −4.18
  OCLoss Inferior Occipital Gyrus/Middle Occipital Gyrus/Fusiform Gyrus/Inferior Temporal Gyrus 19 R 33 −72 −3 240 4.16
Middle Occipital Gyrus/Inferior Occipital Gyrus 19 L −36 −84 0 135 3.64
Middle Temporal Gyrus/Superior Temporal Gyrus 21 L −57 −48 3 137 3.57
Parahippocampal Gyrus/Posterior Cingulate/Middle Temporal Gyrus 30 L −24 −51 0 184 −3.66

A1Loss, prospect of loss phase; A1Win, prospect of reward phase; A2L, anticipation of loss; A2Win, anticipation of reward; BA, Brodmann area; k, voxel cluster size (each voxel = 3 mm3); L, left; MIDT, Monetary Incentive Delay Task; MNI, Montreal Neurological Institute; OCLoss, notification of loss; OCWin, notification of reward; OFC, orbitofrontal cortex; R, right; vmPFC, ventromedial prefrontal cortex; other abbreviations as in Table 1.

a

With a conservative Bonferroni-correction for multiple comparisons between different reward phases, these clusters do not survive correction.