Table 2.
Temporal trends of celiac disease in patients with diarrhea or weight loss (classical symptoms)
| CD Symptoms | 2000–01 (n=26) |
2002–04 (n=67) |
2005–07 (n=83) |
2008–10 (n=73) |
Temporal trend p- value |
|
|---|---|---|---|---|---|---|
| Diarrhea WITHOUT Weight Loss | ||||||
| Proportion of Cases with Symptom† | ||||||
| Total | 4 (15%) | 22 (33%) | 16 (19%) | 23 (32%) | 0.557 | |
| Incidence of Symptom-Related CD‡ | ||||||
| Total | 1.6 (0.0–3.2) | 5.6 (3.2–7.9) | 4.4 (2.2–6.5) | 5.5 (3.2–7.7) | 0.136 | |
| Females | 2.4 (0.0–5.1) | 6.5 (3.0–10.1) | 4.1 (1.2–6.9) | 6.3 (3.0–9.6) | ||
| Males | 0.8 (0.0–2.3) | 4.6 (1.6–7.7) | 4.9 (1.4–8.5) | 4.8 (1.6–8.1) | ||
| Diarrhea WITH Weight Loss | ||||||
| Proportion of Cases with Symptom† | ||||||
| Total | 4 (15%) | 4 (6%) | 4 (5%) | 2 (3%) | 0.044 | |
| Incidence of Symptom-Related CD‡ | ||||||
| Total | 1.9 (0.0–3.8) | 1.0 (0.0–1.9) | 1.2 (0.0–2.3) | 0.6 (0.0–1.3) | 0.168 | |
| Females | 1.7 (0.0–4.2) | 1.0 (0.0–2.4) | 1.6 (0.0–3.3) | 0.6 (0.0–1.7) | ||
| Males | 2.2 (0.0–5.3) | 0.9 (0.0–2.2) | 0.8 (0.0–2.3) | 0.5 (0.0–1.4) | ||
†
Frequency of classical symptoms in CD cases summarized with counts and percentages and tested for a temporal trend using a generalized logit model after adjusting for age and gender.
‡
Incidence described with age-adjusted (and sex-adjusted for bolded “Total” results) incidence rates and 95% confidence intervals (per 100,000 person-years adjusted to the US white population in 2000), with rates tested for a temporal trend via Poisson regression after adjusting for age and gender.