Table 2. Nomenclature and parametric input values of the presented mathematical model as derived here and extracted from the literature.

Parameter	Description	Relation or value
α1	Synthesis rate (cytokine)	α1 = 0.048 + β1
α2	Synthesis rate (growth factor)	α2 = 0.048 + β2
β1	Decay rate (cytokine)	${\beta }_1=\frac{1}{{\tau }_1}\left\{\frac{{\Omega }_2-G_0}{G_0+1-{\Omega }_2}\right\}$
β2	Decay rate (growth factor)	${\beta }_1=\frac{1}{{\tau }_1}\left\{\frac{{\Omega }_2-G_0}{G_0+1-{\Omega }_2}\right\}$
λ1	Synthesis rate (GAG)	5.474 × 10−3 [a]
λ2	Synthesis rate (collagen)	5.400 × 10−2 [a]
δ1	Decay rate (GAG)	1.264 × 10−4 [a]
δ2	Decay rate (collagen)	1.108 × 10−3 [a]
Ω1	Threshold value (growth factor)	C0 − 1 < Ω1 < C0
Ω2	Threshold value (cytokine)	G0 < Ω2 < G0 + 1
τ1	Characteristic time (cytokine)	20.704 weeks [b]
τ2	Characteristic time (growth factor)	22.897 weeks [b]

Note: Concentration values are in relative units (normalised by steady state saturation and scaled for plotting) and kinetic rates (synthesis or decay) are per time (in weeks).

Source:

^aFrom Saha et al. (2005), as derived from Wilson et al. (2002);

^bFrom Li et al. (2002)