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. 2013 Jun 19;7:93. doi: 10.3389/fncel.2013.00093

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Copyright © 2013 Vitalis, Ansorge and Dayer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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5-HT levels impact the migration of GABAergic and glutamatergic neurons. (A) 5-HT immunoreactivity is present in the marginal zone (MZ) and in the intermediate zone (IZ) at embryonic day E17.5, a time point when pyramidal neurons and cortical interneurons are migrating to constitute upper cortical layers. Upper-layer pyramidal neurons (in red) are labeled through electroporation of progenitor cells in the dorsal pallium at E14.5 or E16.5 with a Tomato-expressing plasmid and interneurons are labeled using GAD65-GFP or 5-HT_3A-GFP transgenic mice. (B) Time-lapse imaging on cortical slices revealed that an excess of 5-HT and 5-HT₆ manipulation affects the migration of cortical interneurons (B1) and pyramidal neurons (B2) in a reversible manner. Scale bar: 10 μm.