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Changes in joint space narrowing (JSN) by time-averaged 28-joint disease activity score (TA-DAS28(C-reactive protein (CRP))) tertiles. Changes in JSN are shown over 52 weeks (A) and 104 weeks (B) by tertiles of TA-DAS28(CRP). **p<0.01 for treatment group difference compared with methotrexate (MTX) monotherapy; ***p<0.001. Figures show the median (solid line), mean (dotted line) and IQR (bars). ADA, adalimumab.
