Figure 3.

Pattern of spontaneous Ca²⁺ activity in isochronal maps from FIC (A) and normal (B) cat bladder strips. FIC cat bladder strip shows that Ca²⁺ activity originated in mucosa, while in normal bladder strip activity originates in detrusor. Isochronal delay was 0.12 milliseconds for each map. White areas indicate earliest Ca²⁺ transients. Darker areas indicate later time points. Histological micrographs reveal normal (C) and FIC (D) cat bladder wall. Black bars indicate urothelial, lamina propria and muscle layers, respectively (C). Reduced from ×40.