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. Author manuscript; available in PMC: 2013 Jun 19.
Published in final edited form as: J Urol. 2009 Jan 20;181(3):1415–1422. doi: 10.1016/j.juro.2008.10.138

Figure 4.

Figure 4

Optical mapping response of FIC and normal cat bladder strip to 50 nM arecaidine. Isochronal maps (A) were generated from Ca2+ transients (B) recorded simultaneously in FIC and control cat bladder strips after treatment with 50 nM arecaidine with isochronal delay of 0.15 milliseconds each. Ca2+ transients showed that activity was initiated in FIC strip mucosa and in control strip detrusor. Overlay (C) of Ca2+ transients from 1 pixel at earliest initiation site (black trace) with tension measurements from 2 strips (red trace) shows that mucosal transients precede and drive contractions in FIC strip, indicating that enhanced spontaneous activity originated from mucosal layer of FIC strip and not of normal bladder strip.