Figure 5.

Substitution patterns of the properties of amino acid residues caused by cSNPs. The substitutions that did not alter the properties of amino acid residues are indicated by grey bars. The substitutions related to changes in polarity, e.g. to polar and to non-polar, are shown by dotted and slated bars, respectively. The substitutions related to changes in charges or amino acid residues, i.e. negatively charged (acidic) or positively charged (basic), are shown by white bars. The substitutions related to nonsense mutations are shown by black bars.