Table 3.
Clinical Features by Diagnosis at 6 Months
| Clinical Feature | Diagnosis | ||||
|---|---|---|---|---|---|
| Schizophrenia | Major Depressive Disorder With Psychotic Features | Bipolar Disorder | Bipolar Disorder Without Psychotic Features | Bipolar Disorder With Psychotic Features | |
| Psychopathology | |||||
| PANSS positive | 17.4 (6.4) [54] | 14.7 (6.5) [37] | 16.3 (8.1) [45] | 10.9 (5.0) [7] | 17.3 (8.3)* [38] |
| PANSS negative | 21.7 (7.4) [54] | 17.3 (8.3)** [37] | 9.5 (4.0)*** [45] | 8.0 (1.5) [7] | 9.7 (4.3) [38] |
| Neuropsychology | |||||
| MMSE | 28.1 (2.2) [51] | 27.4 (2.6) [36] | 28.1 (2.1) [39] | 28.6 (2.2) [7] | 27.9 (2.1) [38] |
| NART | 22.6 (11.5) [46] | 23.0 (8.9) [30] | 26.5 (9.8) [36] | 28.1 (14.3) [7] | 26.1 (8.7) [29] |
| EXIT | 8.4 (4.5) [46] | 9.9 (4.2) [33] | 6.9 (5.3)**** [39] | 4.8 (2.1) [6] | 7.3 (5.6) [33] |
| Neurology | |||||
| NES | 14.2 (8.1) [47] | 18.7 (11.0) [30] | 10.3 (8.0)** [34] | 6.3 (7.7) [6] | 11.1 (7.9) [28] |
| SAS | 3.9 (3.4) [50] | 4.1 (3.7) [33] | 2.7 (3.6) [43] | 0.9 (0.9) [7] | 3.1 (3.8) [36] |
| AIMS | 1.3 (2.5) [51] | 0.9 (1.4) [33] | 0.7 (2.0) [44] | 0.0 (0.0) [7] | 0.8 (2.2) [37] |
| Premorbid adjustment | |||||
| PAS-total | 23.3 (7.0) [42] | 26.2 (10.9) [25] | 19.9 (8.2)**** [30] | 20.7 (5.6) [6] | 19.7 (8.8) [24] |
| PAS-1 | 10.6 (3.1) [42] | 12.6 (4.4)** [25] | 9.5 (4.0) [30] | 9.8 (2.2) [6] | 9.4 (4.3) [24] |
| PAS-2 | 12.7 (4.8) [42] | 13.6 (6.8) [25] | 10.4 (4.3) [30] | 10.8 (3.3) [6] | 10.3 (4.6) [24] |
| Quality of life | |||||
| QLS-total | 65.5 (20.6) [45] | 76.1 (28.0) [28] | 100.3 (22.3)*** [37] | 104.6 (16.1) [7] | 99.3 (23.6) [30] |
Note: PANSS, Positive and Negative Syndrome Scale; MMSE, Mini-Mental State Examination; NART, National Adult Reading Test; EXIT, Executive Interview; NES, Neurological Evaluation Scale; SAS, Simpson-Angus Scale; AIMS, Abnormal Involuntary Movement Scale; PAS, Premorbid Adjustment Scale; QLS, Quality of Life Scale.
Data are mean (SD) [number of cases].
*P < .05 vs bipolar disorder without psychotic features, **P < .05, ***P < .001 vs schizophrenia, and ****P < .05 vs major depressive disorder with psychotic features.