Table 3.
Summary of replication results for the association of the SNPs rs806365, rs806366 and rs806369 with insulin-resistance traits, fasting glucose and risk of diabetes in the following datasets: meta-analysis of the NHANES-III and Partners databases combined; MAGIC; and DIAGRAMa.
| HOMA-IR | Fasting glucose | Fasting insulin | Risk of T2D | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| SNP | Risk allele/other | N | β (SE) | P value | N | β (SE) | P value | N | β (SE) | P value | N | OR (CI) | P value |
| NHANES-PARTNERS | |||||||||||||
| rs806365 | C/T | 2,540 | 0.037 (0.014) | 0.007 | 2,551 | 0.020 (0.013) | 0.12 | 2,553 | 0.036 (0.013) | 0.004 | |||
| rs806366 | T/C | 2,573 | −0.009 (0.013) | 0.49 | 2,584 | −0.006 (0.013) | 0.66 | 2,586 | −0.011 (0.012) | 0.35 | |||
| rs806369 | T/C | 2,579 | 0.016 (0.014) | 0.27 | 2,590 | 0.005 (0.014) | 0.7 | 2,592 | 0.017 (0.013) | 0.19 | |||
|
| |||||||||||||
| MAGIC | |||||||||||||
| rs806365 | T/C | 29,248 | 0.001 (0.003) | 0.74 | 34,558 | 0.008 (0.004) | 0.07 | 29,561 | 0.001 (0.003) | 0.72 | |||
|
| |||||||||||||
| DIAGRAM | |||||||||||||
| rs806365 | T/C | 10,128 | 1.00 (0.94–1.07) | 0.31 | |||||||||
Abbreviations: SNP = single nucleotide polymorphism. HOMA-IR: Homeostasis Model Assessment for Insulin Resistance.
SE: standard error. T2D: type 2 diabetes. OR: odds ratio. CI: confidence interval.
NHANES: National Health and Nutrition Examination Survey III (28). Partners: Massachusetts General Hospital plus Brigham and Women’s Hospital case-control diabetes study database (29). MAGIC: The Meta-Analyses of Glucose and Insulin-related traits Consortium database (30). DIAGRAM: The Diabetes Genetics Replication and Meta-analysis (31).
All P values are nominal. Results from the meta-analysis of the NHANES III and Partners cohorts and from MAGIC are age-, sex-, BMI-adjusted, whereas those from DIAGRAM are not BMI-adjusted.