Skip to main content
. Author manuscript; available in PMC: 2013 Jun 19.
Published in final edited form as: Trends Parasitol. 2009 Aug 28;25(9):423–431. doi: 10.1016/j.pt.2009.05.011

Figure 1.

Figure 1

Antibody responses to cercarial secretions in baboons receiving five exposures to irradiated cercariae at 4 week intervals before challenge with normal cercariae at 3 or 12 weeks after the last vaccination [38]. The saw-tooth response reveals that persistent antigenic pressure is needed to increase IgG titre. When that is removed, it rapidly falls, and with it the level of protection. This decline is one reason why we have not sought to emulate malaria researchers [77] by advocating the development of the irradiated cercaria vaccine for human use.