Table 1.
Genes that showed a hair phenotype
| gene | RNAi line or mutant |
Split hairs (dyl-like) |
Thin hairs (dyl-like) |
Faint hairs (kkv-like) |
ect like hairs | Hair cup (dyl-like) | Misaligned hairs |
Cuticle defects |
Reason for screening* |
Comment |
|---|---|---|---|---|---|---|---|---|---|---|
| dyl (CG15013) | V102166 V39022 V39023 dylMI |
+++ | +++ | ++ | +++ | + | 32, 40, d, l, m | ZP domain | ||
| Cht6 (CG43374) | V107916 V38886 |
+ | ++ | + | ++ | +/− | 40, l | Chitinase | ||
| ect (CG6611) | V104650 | + | ++ | + | + | 32, 40, d, m | ||||
| CG15020 | V101086 | +/− | + | 32, d | ZP domain | |||||
| Cyp301a1 (CG8587) | V109771 V26989 |
+/− | 40, d | Curved hairs | ||||||
| kkv (CG2666) |
kkv1 V100327 |
+++ | + | 40, k, l | Chitin synthase1 | |||||
| knk (CG6217) |
knkf01902 V106302 |
+++ | + | 40, k, l | Chitin stability | |||||
| CG5873 | V14374 | + | + | 40, k | Haem peroxidase | |||||
| mtg (CG7549) | V108951 | + | 32, d, l, m | Chitin binding | ||||||
| CG15211 | V104929 | + | + | + | 32, 40 | MARVEL domain | ||||
| cyr (CG15335) | V28555 | +/− | 32, 40, m | ZP domain | ||||||
| uif (CG9138) | V101153 | + | 32, 40 | Lectin, EGF domain | ||||||
| mey (CG12063) | V106568 | +/− | 32, m | ZP domain | ||||||
| CG12206 | V14558 | +/− | +/− | 32 | ||||||
| ed (CG12676) | V104279 V27044 |
+ | + | 32 | Cell - cell adhesion | |||||
| CG30463 | V4923 | +/− | 32 | Glycosyltransfe rase Ricin B lectin |
||||||
| Rab23 (CG2108) | T28025 | + | 32, l | Multiple hair cells | ||||||
| sha (CG13209) | V36512 Several alleles |
+ | ++ | 32, l, m | Localizes to growing hairs | |||||
| CG10933 | V104282 | + | 32 | Src homology 3 domain | ||||||
| svb (CG6824) | V41584 | +++ | ++ | + | + | + | 32, l | Transcription factor | ||
| CG3036 | V108500 | + | 40 | MFS transporter family | ||||||
| CG16953 | V109873 | ++ | 40 | |||||||
| CG14770 | V106550 | +/− | 40 | |||||||
| Cpr97Eb (CG15884) | V19545 | +/− | +/− | 40 | Cuticle protein | |||||
| Cpr49Ah (CG8515) | V23183 | +/− | +/− | 40 | Cuticle protein | |||||
| Eip71CD (CG7266) | V26009 | +/− | 40 | methionine-(S)- S-oxide reductase |
||||||
| CG13917 | V32082 | +/− | + | ++ | 40 | BTB/POZ | ||||
| karst (CG12008) | V37074 | +/− | 40 | βH-spectrin | ||||||
| UGP (CG4347) | V109632 | + b | + | +/− | + | 40 | UTP:glucose-1- phosphate uridylyltransfer ase |
|||
| pwn (CG11101) | V101282 pwn1 |
+/− b | +++ | d, l, m | EGF domains | |||||
| dy (CG9355) | V102255 dy1 |
+++ | d, l | ZP domain | ||||||
| CG15740 | V107087 | +/− | + | d, m | ||||||
| CG42331 | V104585 | +/− | + | d | peroxidase | |||||
| m (CG9369) | V8036 m1, mD |
++ | + | + | +++ | d, m | ZP domain | |||
| CG9095 | V104608 | + tip | + | d, m | C type lectin | |||||
| CG43366 | V101186 | +/− | d | Endopeptidase inhibitor |
||||||
| CG14107 | V102232 | +/− | + | d, m | ||||||
| CG6347 | V101253 | + | d | peptidase | ||||||
| CG15080 | V106073 | + | d | |||||||
| CG15017 | V103326 | +/− | d | |||||||
| CG31559 | V33967 | + | +/− | +/− | d, m | |||||
| CG13188 | V102370 | + | k | Smad domain | ||||||
| CG10232 | V100033 | + | + | d | peptidase | |||||
| CG1869 | V104445 | +/− | +/− | k | Chitinase 7 | |||||
| Syn1 (CG7152) | V104992 | +/− | +/− | k | ||||||
| TwdlE (CG14534) | V107483 | +/− | k |
*
32 – Increased expression at 32 hr awp from Ren et. al., 2005
40 – Increased expression at 40 hr awp from Ren et. al., 2005
d – Expression similar to dyl FlyBase McQuilton et. al., 2012
k – Expression similar to kkv Flybase McQuilton et. al., 2012
m – mE2 34 mRNA expression cluster 07 ModEncode - FlyBase
l – literature