Table 3.
Multivariate Analysis of Factors Predictive of Completion of Chemotherapy
| Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|
| OR(95% CI) | P | OR(95% CI) | P | |
| Female Gender | 0.46 (0.14–1.51) | 0.20 | ||
| Race (White) | 2.05 (0.22–18.97) | 0.53 | ||
| Cancer | ||||
| Lymphoma | Ref | 0.25 | ||
| Colorectal | 0.81 (0.21–3.10) | |||
| Breast | 3.33 (0.34–32.96) | |||
| Lung | 0.25 (0.041–1.52) | |||
| Living Situation | ||||
| Single Family | Ref | 0.62 | ||
| Nursing | 0.36 (0.021–6.08) | |||
| Independent living | 0.36 (0.021–6.08) | |||
| Caregiver | 0.73 (0.17–3.05) | 0.66 | ||
| Falls | 0.24 (0.06–1.04) | 0.056 | ||
| Curative Intent | 4.37 (1.33–14.33) | 0.015 | 4.97 (1.21–18.81) | 0.03 |
| Depression | 1.05 (0.28–3.93) | 0.95 | ||
| ADL dependence | 0.47 (0.093–2.35) | 0.36 | ||
| IADL dependence | 0.33 (0.10–1.06) | 0.06 | * | |
| Cognitive impairment | 0.71 (0.06–8.46) | 0.79 | ||
| ECOG PS 2–3 | 0.18 (0.04–0.77) | 0.02 | 0.089 (0.015– 0.530) | 0.008 |
| Comorbidities (moderate-severe) | 0.47 (0.15–1.49) | 0.20 | ||
| Anemia | 0.62 (0.17–2.21) | 0.46 | ||
| Age | 0.92 (0.84–1.01) | 0.070 | ||
| Body Mass Index | 1.06 (0.96–1.17) | 0.23 | ||
| Creatinine Clearance (OR per ml/min) | 1.027 (1.001–1.054) | 0.04 | 1.03 (1.00–1.06) | 0.04 |
*
Not entered in multivariate model due to strong correlation with performance status
OR, odds ratio; CI, confidence intervals; ADL, activities of daily living; IADL, instrumental activities of daily living; ECOG PS, Eastern Cooperative Oncology Group Performance Status.