Table 4.
Factors Predictive of Grade III/IV Non-Hematologic Toxicity
| Univariate | Multivariate | |||
|---|---|---|---|---|
| OR(95% CI) | P | OR (95% CI) | P | |
| Female Gender | 0.29 (0.094–0.90) | 0.03 3 | 0.20 (0.01–0.75) | 0.017 |
| Race (White) | * | 0.16 | ||
| Cancer | ||||
| Lymphoma | Ref | 0.22 | ||
| Colorectal | 0.43 (0.12–1.55) | |||
| Breast | 0.12 (0.013–1.13) | |||
| Lung | 0.92 (0.16–5.2) | |||
| Living Situation | ||||
| Single Family | Ref | 0.99 | ||
| Nursing | * | |||
| Independent living | * | |||
| Caregiver | 1.023 (0.27–3.85) | 0.97 | ||
| Falls | 1.97 (0.47–8.37) | 0.36 | ||
| Curative Intent | 1.62 (0.52–5.10) | 0.41 | ||
| Depression | 2.92 (0.85–10.04) | 0.09 0 | ||
| ADL dependence | 1.78 (0.36–8.88) | 0.48 | ||
| IADL dependence | 1.62 (0.53–4.98) | 0.40 | ||
| Cognitive impairment | * | 0.55 | ||
| ECOG PS 2–3 | 2.64 (0.66–10.54) | 0.17 | ||
| Comorbidities (moderate-severe) | 4.40 (1.39–13.96) | 0.01 2 | 6.13 (1.65–22.74) | 0.007 |
| Anemia | 1.31 (0.37–4.61) | 0.67 | ||
| Age | 1.02 (0.94–1.11) | 0.67 | ||
| Body Mass Index | 1.09 (0.99–1.19) | 0.07 4 | ||
| Creatinine Clearance (ml/min) | 0.98 (0.96–1.00) | 0.10 | ||
*
Not estimable due to 0 count of toxicity in the cell.
OR, odds ratio; CI, confidence intervals; ADL, activities of daily living; IADL, instrumental activities of daily living; ECOG PS, Eastern Cooperative Oncology Group Performance Status; CrCl, creatinine clearance.