Risk score calculated from SIGLEC12 rs16982743, A1BG rs893184, and F5 rs4525. One point was given for each genotype that conferred higher risk in the CCB arm/group versus the βB arm/group: rs16982743 GG (Gln/Gln), rs893184 GG (Arg/Arg), and rs4525 AA (His/His). Low Risk defined as a risk score = 0 or 1; High Risk defined as a risk score = 2 or 3.
#: One-sided P-value based on one-sided hypothesis in replication cohort.