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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Exp Cell Res. 2013 Apr 6;319(9):1247–1254. doi: 10.1016/j.yexcr.2013.03.028

Figure 1.

Figure 1

Balancing migration and cell-cell adhesion. In response to growth factor cues (in this example VEGF, pink), the migratory endothelial cell will orient filopodia and lamellipodia to the leading front while the cell undergoes cytoskeletal rearrangement. Caveolin1 interacts with 31 integrin as the cell migrates, and participates in the endocytosis and recycling of integrins. In response to polarity and matrix cues, RhoA is initiated at the site of protrusion and actin assembly. Cdc42 and Rac1 function to propagate the initiating event. Amot and AmotL1 interact with Syx (and can interact with each other) to regulate RhoA both at the cell-cell tight junctions (TJ) and in the polarized leading edge. Phosphorylated VEGFR2 (pVEGFR) is co-trafficked with Amot and Syx and function in TJ disassembly. TJ is represented by Occludin, ZO-1 and VE-cadherin.