Table 3.
Results of logistic regression models for retinopathy among probands with T1D.
| Allele/haplotype | Total probands N (%) | Cases N (%) | Controls N (%) | Unadjusted OR (95% CI), p-value | Adjusted ORa (95% CI), p-value |
|---|---|---|---|---|---|
| No. of DR-typed subjects | 400 | 111 | 289 | ||
| DRBl *03:01-negative | 151 (37.7) | 50 (45.1) | 101 (34.9) | Referent | Referent |
| DRBl *03:01-positive | 249 (62.3) | 61 (54.9) | 188 (65.1) | 0.66 (0.42, 1.02), 0.063 | 0.58 (0.35, 0.96), 0.031 |
| DRBl *04:01 -negative | 205 (51.3) | 52 (46.8) | 153 (52.9) | Referent | Referent |
| DRBl *04:01 -positive | 195 (48.8) | 59 (53.2) | 136 (47.1) | 1.28 (0.82, 1.98), 0.275 | 1.17 (0.72, 1.92), 0.520 |
| No. of DQ-typed subjects | 425 | 119 | 306 | ||
| DQAl *03:01-DQBl *03: 02-negative | 150 (35.3) | 43 (36.1) | 107 (35.0) | Referent | Referent |
| DQAl *03:01-DQBl *03: 02-positive | 275 (64.7) | 76 (63.9) | 199 (65.0) | 0.95 (0.61, 1.48), 0.821 | 0.85 (0.51, 1.41), 0.531 |
| DQAl *05:01-DQBl *02: 01-negative | 179 (42.1) | 59 (49.6) | 120 (39.2) | Referent | Referent |
| DQAl *05:01-DQBl *02: 01-positive | 246 (57.9) | 60 (50.4) | 186 (60.8) | 0.66 (0.43, 1.00), 0.053 | 0.58 (0.36, 0.95), 0.029 |
| No. of HLA-B-typed subjects | 416 | 119 | 297 | ||
| HLA-B*39:06-negative | 385 (92.5) | 107 (89.9) | 278 (93.6) | Referent | Referent |
| HLA-B*39:06-positive | 31 (7.5) | 12 (10.1) | 19 (6.4) | 1.64 (0.77, 3.50), 0.199 | 3.34 (1.34, 8.30), 0.01 |
a
Adjusted for sex, age at type 1 diabetes diagnosis, duration of type 1 diabetes.