Figure 11.

A, Traces showing spontaneous firing in the cell-attached mode from WT and BACHD PLTS cells from the 2 month age group. Right bar graphs show that spontaneous action potential firing in PLTS interneurons from BACHD mice was significantly increased when compared with those of WTs at both ages (p < 0.05, t test for comparisons at 2 months, Mann–Whitney U test for comparison at 12 months). B, Amplitude-frequency histograms of sIPSCs from PLTS interneurons from WT and BACHD mice at 2 and 12 months (insets are averages). There was a significant reduction in mean frequency of sIPSCs in BACHD PLTS neurons, mainly in the small amplitude events, compared with those of WTs at both 2 and 12 months but no difference in mean sIPSC amplitudes. C, Amplitude-frequency histograms of sIPSCs from FS interneurons from WT and BACHD mice at 2 and 12 months (insets are averages). There was a significant increase in the mean frequency of sIPSCs in BACHD FS neurons, mainly in the small amplitude events, compared with those of WTs at both 2 and 12 months but no difference in mean sIPSC amplitudes.