Figure 7.

A, Traces showing a PLTS interneuron from a WT mouse identified electrophysiologically by a depolarized RMP and time-dependent “sag” upon hyperpolarization, as well as the presence of plateau depolarizations and rebound excitation. B, Traces of spontaneous action potentials recorded in current-clamp mode from WT and R6/2 PLTS interneurons. Note the increased spontaneous firing and bursting in the PLTS neurons from R6/2 mice. C, Bar graph shows that there was a significantly higher frequency of spontaneous firing in PLTS interneurons from R6/2 compared with WT mice.