Table 4.
Genes most significantly differentially expressed by bMEC stimulated by LPS for 3 and 6 h compared to unstimulated cells, ordered by functional classes
| Gene symbol | Gene description |
Fold change |
|
|---|---|---|---|
| 3 h | 6 h | ||
|
Transcription and activation pathways |
|
|
|
| NFKBIA |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
3.60 |
4.53 |
| BIRC3 |
Baculoviral IAP repeat-containing protein 3 |
3.10 |
3.19 |
| ZNFX1 |
NFX1-type zinc finger-containing protein 1 |
|
3.11 |
| ZNHIT3 |
Zinc finger HIT domain-containing protein 3 |
2.48 |
3.08 |
| IKBKAP |
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
2.52 |
2.33 |
| TRIM21 |
Tripartite motif-containing protein 21 |
1.61 |
2.26 |
| CEBPD |
CCAAT/enhancer binding protein (C/EBP), delta |
2.02 |
1.60 |
| NFKB2 |
Nuclear factor of κ light polypeptide gene enhancer in B-cells 2 |
1.78 |
1.94 |
| JAK2 |
Janus kinase 2 |
1.90 |
1.85 |
| DUSP1 |
Dual specificity phosphatase 1 |
|
1.85 |
| FOS |
V-fos |
|
-2.01 |
| PLK2 |
Serum-inducible kinase, transcript variant 1,PLK2 |
-1.50 |
|
|
Cytokines and chemokines, growth factors |
|
|
|
| CCL5 |
RANTES |
7.10 |
20.52 |
| CCL20 |
Chemokine (C-C motif) ligand 20 |
19.42 |
19.37 |
| CXCL8 |
Chemokine (C-X-C motif) ligand 8, Interleukin-8 |
8.53 |
13.96 |
| CXCL5 |
Chemokine (C-X-C motif) ligand |
4.75 |
7.96 |
| CCL2 |
Chemokine (C-C motif) ligand 2 |
|
6.38 |
| CXCL2 |
Chemokine (C-X-C motif) ligand 2 |
|
5.06 |
| CXCL1 |
Chemokine (C-X-C motif) ligand 1 |
4.93 |
|
| IL6 |
Interleukin 6 |
6.64 |
4.85 |
| CXCL3 |
Chemokine (C-X-C motif) ligand 3 |
3.15 |
3.60 |
| IL1B |
Interleukin 1, beta |
5.01 |
3.32 |
| IFNB |
Interferon beta precursor |
4.89 |
3.25 |
| TNFSF13B |
Tumor necrosis factor (ligand) superfamily, member 13 (BAFF) |
2.96 |
|
| IL2 |
Interleukin 2 |
4.30 |
2.86 |
| CCL16 |
Chemokine (C-C motif) ligand 16 |
2.60 |
2.77 |
| CSF2 |
Colony stimulating factor 2 (granulocyte-macrophage) |
1.69 |
2.10 |
| IL23A |
Interleukin 23, alpha subunit p19 |
|
2.06 |
| CTGF |
Connective tissue growth factor |
-1.92 |
|
| TGFB2 |
Transforming growth factor beta-2 precursor |
|
-1.46 |
|
Type I IFN-related genes |
|
|
|
| IFIT3 |
Interferon-induced protein with tetratricopeptide repeats 3 |
3.02 |
7.92 |
| MX1 |
Myxovirus (influenza virus) resistance 1 |
1.84 |
2.93 |
| IFIH1 |
Interferon induced with helicase C domain 1 |
2.65 |
4.10 |
| ISG15 |
ubiquitin-like modifier |
2.46 |
3.69 |
| GBP1 |
Interferon-induced guanylate-binding protein 1 |
2.17 |
3.56 |
| TNFSF10 |
Tumor necrosis factor ligand superfamily member 10 (TRAIL) |
2.02 |
3.13 |
| IFI44 |
Similar to Interferon-induced protein 44 |
|
3.23 |
| OAS1 |
2′-5′-oligoadenylate synthetase 1 |
1.61 |
3.15 |
| IFI27L1 |
Interferon alpha-inducible protein 27-like protein 1 |
|
2.88 |
| IRF7 |
Interferon regulatory factor 7 |
1.45 |
2.75 |
| TRIM21 |
Tripartite motif-containing protein 21 |
1.61 |
2.26 |
| GVIN1 |
GTPase, very large interferon inducible 1 |
|
2.21 |
| STAT2 |
Signal transducer and activator of transcription 2 |
|
2.01 |
| STAT1 |
Signal transducer and activator of transcription 1 |
|
1.96 |
| IRF2 |
Interferon regulatory factor 2 |
|
1.84 |
|
Immune defense response |
|
|
|
| NOS2A |
Nitric oxide synthase 2A (inducible) |
5.57 |
7.45 |
| S100A8 |
Calcium-binding protein A8, calgranulin A |
2.87 |
7.00 |
| CFB |
Complement factor B |
3.39 |
5.02 |
| S100A9 |
Calcium-binding protein A9, calgranulin B |
2.40 |
4.59 |
| CD83 |
Cell surface protein HB15 |
5.50 |
3.40 |
| C2 |
C2 Complement component 2 |
1.79 |
2.64 |
| ICAM1 |
Intercellular adhesion molecule 1 |
2.50 |
|
| LTF |
Lactotransferrin |
|
2.47 |
| PLAT |
Plasminogen activator, tissue type |
1.93 |
2.11 |
| PLAUR |
Urokinase plasminogen activator surface receptor |
2.11 |
1.96 |
| CAMP |
Cathelicidin antimicrobial peptide |
|
1.89 |
| TLR4 |
Toll-like receptor 4 |
1.62 |
1.81 |
| MMP9 |
Matrix metallopeptidase 9 |
|
1.77 |
| CD74 |
Major histocompatibility complex, class II invariant chain |
|
1.75 |
| BNBD10 |
Beta-defensin 10 |
1.59 |
1.67 |
|
Stress response |
|
|
|
| SOD2 |
Superoxide dismutase 2 |
3.19 |
5.05 |
| SGK1 |
Serum/glucocorticoid regulated kinase 1 |
1.81 |
4.79 |
| PARP14 |
Poly (ADP-ribose) polymerase family, member 14 |
|
2.95 |
|
Cell growth and cycle, apoptosis |
|
|
|
| IGFBP3 |
Insulin-like growth factor binding protein-3 |
2.38 |
5.27 |
| EIF4E |
Translation initiation factor 4E |
2.32 |
5.20 |
| CASP4 |
Caspase-4 Precursor |
1.60 |
3.04 |
| CASP8 |
Caspase-8 precursor |
1.58 |
2.29 |
| IER3 |
Immediate early response 3 |
2.09 |
|
| TNFRSF6 |
TNF receptor superfamily, member 6 (FAS) |
1.82 |
1.86 |
| CDK2AP1 |
Cyclin-dependent kinase 2 associated protein 1 |
|
-1.66 |
| EI24 | Etoposide-induced protein 2.4 homolog | -1.65 | |