Table 5.
Genes most significantly differentially expressed by bMEC stimulated by SaS for 3 and 6 h compared to unstimulated cells, ordered by functional classes
| Gene symbol | Gene description |
Fold change |
|
|---|---|---|---|
| 3 h | 6 h | ||
|
Transcription and activation pathways |
|
|
|
| FOS |
Proto-oncogene protein c-fos |
2.09 |
2.21 |
| NFKBIA |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
2.15 |
2.07 |
| DUSP1 |
dual specificity phosphatase 1 |
1.91 |
1.71 |
| ETS2 |
erythroblastosis virus E26 oncogene homolog 2 (avian) |
|
1.72 |
| CEBPD |
CCAAT/enhancer binding protein (C/EBP), delta |
1.65 |
1.59 |
| SQSTM1 |
sequestosome 1 |
|
1.58 |
| BIRC3 |
Baculoviral IAP repeat-containing 3 |
1.56 |
|
| IKBKAP |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
|
1.49 |
| JUN |
Jun oncogene |
1.57 |
1.47 |
| NFKB2 |
nuclear factor of κ light polypeptide gene enhancer in B-cells 2 |
-2.05 |
|
| FUS |
RNA-binding protein FUS |
|
-1.82 |
| SFRS3 |
Splicing factor, arginine/serine-rich 3 |
|
-1.71 |
| SFPQ |
splicing factor proline/glutamine-rich |
|
-1.59 |
| RABL3 |
RAB, member of RAS oncogene family-like 3 |
|
-1.57 |
| U2AF1 |
Splicing factor U2AF |
|
-1.54 |
| CSTF2 |
cleavage stimulation factor, 3′pre-RNA, subunit 2 |
|
-1.53 |
| RDBP |
RNA-binding protein RD, Negative elongation factor E |
|
-1.47 |
| DKC1 |
dyskeratosis congenita 1, dyskerin |
|
-1.47 |
| CRSP9 |
Cofactor required for Sp1 transcriptional activation subunit 9 |
-1.45 |
|
|
Cytokines and chemokines |
|
|
|
| CXCL8 |
Chemokine (C-X-C motif) ligand 8, Interleukin-8 |
6.20 |
4.52 |
| CCL20 |
chemokine (C-C motif) ligand 20 |
4.94 |
4.27 |
| CXCL1 |
Chemokine (C-X-C motif) ligand 1 |
3.51 |
|
| CXCL3 |
Chemokine (C-X-C motif) ligand 3 |
2.48 |
|
| CCL2 |
chemokine (C-C motif) ligand 2 |
2.22 |
2.71 |
| CXCL5 |
chemokine (C-X-C motif) ligand 5 |
|
2.57 |
| CXCL2 |
chemokine (C-X-C motif) ligand 2 |
|
2.47 |
| IL6 |
Interleukin 6 |
1.71 |
|
| VEGFB |
Vascular endothelial growth factor B Precursor |
|
1.47 |
|
Immune defense response |
|
|
|
| PLAUR |
urokinase plasminogen activator surface receptor |
1.70 |
2.46 |
| LBP |
lipopolysaccharide binding protein |
|
2.26 |
| NOS2A |
Nitric oxide synthase 2A (inducible) |
|
2.05 |
| CD83 |
Cell surface protein HB15 |
1.89 |
1.73 |
| CFB |
complement factor B |
|
1.70 |
| SQSTM1 |
sequestosome 1 |
|
1.58 |
| TLR4 |
toll-like receptor 4 |
|
1.50 |
| ILRAP |
interleukin 1 receptor accessory protein |
|
1.44 |
| CD96 |
Cell surface antigen CD96 |
|
1.31 |
| C3 |
Complement factor 3 |
|
-1.35 |
| MMP9 |
Matrix metallopeptidase 9 |
-1.33 |
|
|
Stress response |
|
|
|
| SGK1 |
serum/glucocorticoid regulated kinase 1 |
1.73 |
1.75 |
|
Cell growth and cycle, apoptosis |
|
|
|
| IER3 |
immediate early response 3 |
1.99 |
1.58 |
| RASSF1 |
Ras association domain-containing protein 1 |
|
1.52 |
| CDKN2B |
cyclin-dependent kinase inhibitor 2B |
|
-1.85 |
| CDC20 |
cell division cycle 20 homolog (S. cerevisiae) |
|
-1.60 |
| CCNA2 | cyclin A2 | -1.37 | |