Table 7.
Functional pathways of genes most affected by SaS stimulation, determined by using the Genomatix Pathway System (GePS)
|
SaS vs Ref 3 h (List of 65 genes taken into account) |
|
|
|---|---|---|
| p value | nb of genes | |
|
Signal transduction pathways (canonical) |
|
|
| AP-1 transcription factor network |
5.05 × 10-7 |
6/69 |
|
Signal transduction pathways (Genomatix) |
|
|
| Interleukin 17A |
8.75 × 10-7 |
7/137 |
| Protein kinase B |
1.59 × 10-6 |
9/297 |
| Baculoviral IAP repeat containing protein, |
1.94 × 10-6 |
9/304 |
| apoptosis inhibitor |
|
|
| FBJ murine osteosarcoma viral oncogene |
6.49 × 10-6 |
4/32 |
| homolog B |
|
|
| Cyclin D1 |
7.69 × 10-6 |
10/461 |
| Chemokine (CC motif) ligand 2 |
8.40 × 10-6 |
8/272 |
|
Molecular functions (GO) |
|
|
| Too few genes, p value > 10-5 |
|
|
|
Biological processes (GO) |
|
|
| Too few genes, p value > 10-5 |
|
|
|
SaS vs Ref 6 h (213 genes taken into account) |
|
|
|
Signal transduction pathways (canonical) |
|
|
| Too few genes, p value > 10-5 |
|
|
|
Signal transduction pathways (Genomatix) |
|
|
| Minichromosome maintenance complex |
6.13 × 10-7 |
7/42 |
| Cyclin B1 |
9.29 × 10-7 |
10/112 |
| Cyclin D1 |
2.34 × 10-6 |
19/461 |
| DNA repair |
4.43 × 10-6 |
23/725 |
| Cyclin A2 |
4.37 × 10-6 |
11/167 |
| Checkpoint |
2.51 × 10-5 |
16/402 |
| Interleukin 17A |
4.07 × 10-5 |
10/137 |
| Nuclear receptor subfamily 3, group C |
4.08 × 10-5 |
10/171 |
| Cell cycle |
4.94 × 10-5 |
32/1309 |
| Aryl hydrocarbon receptor |
9.93 × 10-5 |
10/190 |
|
Molecular functions (GO) |
|
|
| Protein binding |
2.95 × 10-5 |
100/8067 |
| Protein heterodimerizaton activity |
1.23 × 10-4 |
9/202 |
| Oxidoreductase activity |
2.39 × 10-4 |
17/685 |
|
Biological processes (GO) |
|
|
| Symbiosis, encompassing mutualism |
2.15 × 10-5 |
6/58 |
| Viral reproduction |
3.84 × 10-5 |
7/94 |
| Cell death |
1.05 × 10-4 |
27/1275 |
| Death |
1.10 × 10-4 |
27/1279 |
| Response to organic substance |
1.24 × 10-4 |
21/874 |
| Oxidation reduction | 1.98 × 10-4 | 17/645 |