Table 3.
Univariate analysis of the association between subclinical atherosclerosis and socio-demographic variables, habits, and metabolic data in individuals infected with HIV by age group, seen at two referral hospitals in the state of Pernambuco, Brazil
| Variables |
< 40 years old (n=351) |
≥ 40 years old (n=346) |
||||
|---|---|---|---|---|---|---|
| % subclinical atherosclerosis | OR(CI) | p-value | % subclinical atherosclerosis | OR(CI) | p-value | |
|
Age (continuous) |
- |
1.17 (1.10 – 1.25) |
< 0.001 |
- |
1.11 (1.06 – 1.16) |
< 0.001 |
|
Gender |
|
|
|
|
|
|
| Female |
18.3 |
1.0 |
- |
62,7 |
1.0 |
- |
| Male |
26.8 |
1.63 (0.96 – 2.75) |
0.067 |
69.2 |
1.33 (0.84 – 2.09) |
0.213 |
|
Race |
|
|
|
|
|
|
| White |
13.3 |
1.0 |
- |
68.2 |
1.0 |
- |
| Nonwhite |
26.8 |
2.38 (1.22 – 4.64) |
0.011 |
65.9 |
0.89 (0.53 – 1.52) |
0.691 |
|
Schooling (years of study) |
|
|
|
|
|
|
| 1 to 12 |
22.3 |
1.0 |
- |
66.4 |
1.0 |
- |
| 13 or more |
32.3 |
1.67 (0.77 – 3.59) |
0.190 |
68.3 |
1.10 (0.58 – 2.10) |
0.759 |
|
Stable partner |
|
|
|
|
|
|
| No |
20.1 |
1.0 |
- |
62.5 |
1.0 |
- |
| Yes |
36.8 |
2.30 (1.30 – 4.08) |
0.004 |
78.6 |
2.19 (1.23 – 3.91) |
0.008 |
|
Smoking |
|
|
|
|
|
|
| No |
24.4 |
1.0 |
- |
66.4 |
1.0 |
- |
| Yes |
19.8 |
0.87 (0.36 – 2.09) |
0.759 |
66.7 |
0.97 (0.46 – 1.93) |
0.929 |
|
Lipodystrophy |
|
|
|
|
|
|
| No |
20.6 |
1.0 |
- |
63.5 |
1.0 |
- |
| Yes |
28.0 |
1.50 (0.88 – 2.54) |
0.131 |
70.2 |
1.35 (0.84 – 2.17) |
0.206 |
|
Metabolic Syndrome |
|
|
|
|
|
|
| No |
17.9 |
1.0 |
- |
63.9 |
1.0 |
- |
| Yes |
49.1 |
4.42 (2.44 – 7.99) |
0,000 |
72.0 |
1.44 (0.87 – 2.38) |
0.147 |
|
Hypertension |
|
|
|
|
|
|
| No |
19.1 |
1.0 |
- |
61.0 |
1.0 |
- |
| Yes |
44.3 |
3.36 (1.87 – 6.03) |
0.000 |
76.9 |
2.12 (1.28 – 3.52) |
0.004 |
|
Waist circumference (cm) |
|
|
|
|
|
|
| Normal |
19.2 |
1.0 |
- |
62.3 |
1.0 |
- |
| Abnormal* |
41.2 |
2.94 (1.66 – 5.18) |
0.000 |
74.7 |
1.64 (0.93 – 2.89) |
0.087 |
|
BMI (kg/m2) |
|
|
|
|
|
|
| < 25 |
15.5 |
1.0 |
- |
60.0 |
1.0 |
- |
| ≥ 25 and < 30 |
32.6 |
2.63 (1.49 – 4.67) |
0.001 |
75.2 |
2.02 (1.19 – 3.42) |
0.008 |
| ≥ 30 |
52.9 |
6.14 (2.86 – 13.2) |
0.000 |
81.2 |
2.88 (1.13 – 7.32) |
0.025 |
|
Total cholesterol (mg/dL) |
|
|
|
|
|
|
| < 200 |
21.7 |
1.0 |
- |
62.6 |
1.0 |
- |
| 200 - <240 |
28.6 |
1.44 (0.69 – 2.98) |
0.323 |
69.4 |
1.35 (0.79 – 2.32) |
0.269 |
| ≥ 240 |
42.1 |
2.62 (1.01 – 6.80) |
0.048 |
83.0 |
2.89 (1.22 – 6.84) |
0.015 |
|
HDL-cholesterol (mg/dL) ** |
|
|
|
|
|
|
| Normal |
24.8 |
1.0 |
- |
64.8 |
1.0 |
- |
| Low |
22.4 |
0.87 (0.52 – 1.44) |
0.596 |
67.7 |
1.13 (0.72 – 1.79) |
0.579 |
|
LDL-cholesterol (mg/dL) |
|
|
|
|
|
|
| < 130 |
22.2 |
1.0 |
- |
61.5 |
1.0 |
- |
| ≥ 130 |
30.4 |
1.53 (0.77 – 3.05) |
0.225 |
82.9 |
3.02 (1.58 – 5.82) |
0.001 |
|
Triglycerides (mg/dL) |
|
|
|
|
|
|
| < 150 |
18.9 |
1.0 |
- |
63.9 |
1.0 |
- |
| ≥ 150 |
31.4 |
1.96 (1.17 - 3.28) |
0.010 |
69.3 |
1.27 (0.80 – 2.01) |
0.296 |
|
Fasting glucose (mg/dL) |
|
|
|
|
|
|
| < 100 |
21.6 |
1.0 |
- |
65.6 |
1.0 |
- |
| ≥ 100 | 35.7 | 2.01 (1.01 – 4.01) | 0.046 | 72.4 | 1.39 (0.81 – 2.38) | 0.227 |
*Men: waist >102 cm; women: waist >88 cm.
**Low HDL-cholesterol < 40 mg/dL in men and < 45 mg/dL in women.