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. 2013 Jun 19;8(6):e66444. doi: 10.1371/journal.pone.0066444

Figure 5. Involvement of tMPT in superoxide flashes excited by proinflammatory cytokines.

Figure 5

A, Preincubation of cyclosporine A (CsA, 1 µM for 30 min) suppressed spontaneous superoxide flashes and blunted their response to cytokines. n = 24–115 cells. B, Effect of CsA and cytokines on superoxide flash amplitude. C, Effect of CsA on cytokine-induced mitochondrial fragmentation, indexed by FAHM. n = 86–969 events. FAHM: full area at half maximum. In A–C, data are reported as the mean ± SEM values. *, p<0.05; **, p<0.01 versus the respective control, IL-1β or TNF-α group.