Table 4.
Clinical response to R-CHOP therapy according to CD20 Exon2[216] Polymorphism
|
Response |
CD20 exon2[216]genotype n (%) |
P Value* | |
|---|---|---|---|
| CC No.(%) | CT + TT No.(%) | ||
| No.(N = 129) |
95 |
34 |
|
| CR |
64(67.4) |
16(47.1) |
0.091 |
| PR |
22(23.2) |
11(32.4) |
|
| SD/PD |
9(9.4) |
7(20.5) |
|
| ORR(CR + PR) |
86(90.6) |
27(79.5) |
0.166#1 |
| CR |
64(67.4) |
16(47.1) |
0.036#2 |
| Non-CR | 31(32.6) | 18(52.9) | |
Abbreviations: CR complete response, PR partial response, SD stable disease, PD progressive disease, ORR (OR + PR), overall response, non-CR, PR + SD + PD.
#1 P = 0.166 when comparing ORR with SD/PD;#2 P = 0.036 when comparing CR with non-CR (PR + SD + PD) ;* χ2 test.