Figure 1. Effect of niacin, simvastatin and their combination on plasma lipid levels.

Plasma total cholesterol (A), triglycerides (B) and HDL-cholesterol levels were measured at various time points throughout the study. The average HDL-cholesterol levels were calculated for all the treatment groups (C). Lipoproteins were separated by FPLC and cholesterol was measured in the fractions after 18 weeks of treatment (D). (Simva, simvastatin; values are means ± SD; n = 15 per group; **P<0.01 and ***P<0.001 as compared to control; ^#P<0.05 and ^###P<0.001 as compared to niacin+simvastatin).