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. 2013 Jun 19;8(6):e66789. doi: 10.1371/journal.pone.0066789

Figure 7. Suppression of induced miRNA-15b prevents impairment of cardiac function.

Figure 7

(A) Reduced expression of miRNA-15b upon anti-miRNA-15b delivery. (B) Representative M-mode images of Dicer−/− and anti-miRNA-15b injected Dicer−/− mice. (C) 11.7T MRI images of long axis at diastole (i & ii) and systole (iii & iv) (D) 11.7T images of short axis at diastole and systole of 1.0 mm slices stacked along columns from base to apex of the left ventricle as explained in Fig. 1. (E) (i) Fractional shortening, (ii) ejection fraction (EF) and (iii) LV mass. (F) (i) Fractional shortening, (ii) ejection fraction and (iii) LV mass in saline or anti-miR-15b injected Dicer+/+ (wild type).