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. 2013 Jun 19;8(6):e65481. doi: 10.1371/journal.pone.0065481

Figure 6. Effect of PD-118057 (3 µM) and thapsigargin (1 µM) on deactivation of hERG channel.

Figure 6

Insert shows the voltage clamp protocol. a-d: Representative deactivation traces in HEK293 cells transfected with WT-hERG or WT/E637K-hERG in the presence or absence of PD-118057 and thapsigargin (arrow marks the deactivation phase). e: Fast and slow components of deactivation time constants (tau, τ) are plotted as a function of test potentials for WT-hERG or WT/E637K-hERG plasmids in the presence or absence of drug (n = 6).