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. 2013 Jun 19;8(6):e65007. doi: 10.1371/journal.pone.0065007

Figure 5. Localization of inflammatory infiltrates in livers of i.p. vs i.g. infected mice.

Figure 5

A. Localization of bacteria-containing infiltrates to the margins of the liver lobes (black) or to the periportal or pericentral region (white). The graph indicates relative numbers determined in five C57BL/6N Wt and Ifnar1−/− mice 48 h post i.p. or i.g. infection. The anti-Listeria staining in the panel on the right indicates marginal and periportal infiltrates from a representative Wt sample 48 h post infection. B. Histochemical analysis of hematoxylin-stained liver sections obtained 24 h, 48 h or 72 h after i.g. and 48 h or 72 h after i.p administration of strain LO28InlA* to C57BL/6N or Ifnar1−/− mice. C, D. Gr1+ (left panels) or TUNEL+ cells (right panels) in inflammatory liver infiltrates. Liver sections obtained 48 h (C) or 72 h (D) after i.g administration of strain LO28InlA* to Ifnar1−/− mice were stained with antibody to Gr1 or subjected to TUNEL staining. GR1+ and TUNEL+ cells appear red. E. Serum ALT levels from i.g.-infected mice. The data are representative of two different experiments with seven mice in each group and time point.