Table 1. Inhibition of cADPR hydrolysis by CD38 for cIDPR and N1-IMP analogue.
Compound | IC50 |
cIDPR analogues | |
8-Amino N1-cIDPR | 56 µM ±9 µM |
cADPcR | 129 µM ±12 µM |
8-Bromo N1-cIDPR | 158 µM ±13 µM |
N1-cIDPR | 276 µM ±10 µM [30] |
8-(4-Aminobutane) | >1 mM |
amino N1-cIDPR | |
N 1-IMP analogues | |
8-Iodo N1-IMP | >1 mM |
8-Bromo N1-IMP | 201 µM ±41 µM |
N1-IMP | 14 µM ±5 µM |
8-Amino N1-IMP | 7.7 µM ±0.2 µM |