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. 2013 Jun 19;8(6):e66247. doi: 10.1371/journal.pone.0066247

Table 1. Inhibition of cADPR hydrolysis by CD38 for cIDPR and N1-IMP analogue.

Compound IC50
cIDPR analogues
8-Amino N1-cIDPR 56 µM ±9 µM
cADPcR 129 µM ±12 µM
8-Bromo N1-cIDPR 158 µM ±13 µM
N1-cIDPR 276 µM ±10 µM [30]
8-(4-Aminobutane) >1 mM
amino N1-cIDPR
N 1-IMP analogues
8-Iodo N1-IMP >1 mM
8-Bromo N1-IMP 201 µM ±41 µM
N1-IMP 14 µM ±5 µM
8-Amino N1-IMP 7.7 µM ±0.2 µM