Table 2.
fMRI responses during the dynamic faces task.
| Angry-Shape | ||||||
| Contrast | Region | Z-score | k | x | y | z |
| Task effects | Right Parahippocampal Gyrus, Hippocampus, Amygdala | 4.72 | 285 | 24 | −14 | −16 |
| mPFC (BA 10/11) | 4.41 | 117 | 0 | 54 | −12 | |
| mPFC (BA 9/10) | 4.62 | 517 | 0 | 62 | 14 | |
| Rostral ACC (BA 32) | 3.37 | 13 | −2 | 44 | 6 | |
| CAPS positive correlation | Right Hippocampus | 3.47 | 26 | 18 | −14 | −16 |
| Left mPFC (BA 10) | 3.51 | 21 | −8 | 66 | 6 | |
| Right Insula (BA 13) | 3.62 | 98 | 46 | −24 | 16 | |
| CES positive correlation | dACC (BA 24) | 3.70 | 85 | 4 | 24 | 34 |
| Left BA 6/43 | 4.00 | 16 | −62 | −10 | 12 | |
| CTQ positive correlation | dACC (BA 24) | 3.88 | 164 | −2 | 24 | 22 |
| Left Inferior Frontal Gyrus (BA 44) | 4.11 | 26 | −52 | 8 | 14 | |
| Right Inferior Frontal Gyrus (BA 6/44) | 4.51 | 26 | 54 | 2 | 20 | |
| DES negative correlation | dACC (BA 24) | 3.43 | 27 | 0 | 30 | 18 |
| Happy-Shape | ||||||
| Contrast | Region | Z-score | k | x | y | z |
| Task effects | Right Parahippocampal Gyrus, Hippocampus, Amygdala, vmPFC (BA 25/47) | 5.61 | 730 | −34 | 6 | −16 |
| vmPFC (BA 11) | 3.79 | 52 | −2 | 56 | −16 | |
| mPFC (BA 10) | 3.51 | 32 | −6 | 60 | 20 | |
| mPFC (BA 9/10) | 3.76 | 12 | −4 | 60 | 30 | |
| DES positive correlation | mPFC (BA 9) | 3.49 | 22 | 6 | 50 | 36 |
| Right Superior Temporal Gyrus | 4.39 | 27 | 66 | −6 | 4 | |
| Left Parietal Lobe (BA 3) | 4.44 | 22 | −50 | −24 | 58 | |
| Left Occipital Lobe (BA 18) | 4.10 | 20 | −18 | −96 | 10 | |
Multivariate regression was conducted in SPM8 to examine the neural correlates of CAPS, CES, CTQ, and DES in the angry-shape and happy-shape contrast conditions. For each emotion contrast, overall task effects are shown, followed by significant correlations with clinical variables. Analyses were controlled for BDI and IQ scores. A priori functional regions of interest (shown in regular type) were identified at p<0.001 uncorrected, with minimum cluster size k=10 voxels. Regions outside of a priori areas (shown in italics) were identified at the more stringent p<0.0001 threshold. CAPS=Clinician-administered PTSD Scale, CES=Combat Exposure Scale, CTQ=Childhood Trauma Questionnaire, BDI=Beck Depression Inventory. vmPFC=ventromedial prefrontal cortex, dACC=dorsal anterior cingulate cortex. k=cluster size. Peak activation coordinates (x, y, z) are based on the Montreal Neurological Institute atlas.