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. Author manuscript; available in PMC: 2013 Jun 19.
Published in final edited form as: Antioxid Redox Signal. 2008 Feb;10(2):303–319. doi: 10.1089/ars.2007.1903

FIG. 2. Potential mechanisms whereby PAI-1 promotes ECM deposition.

FIG. 2

PAI-1 promotes ECM deposition by (a) inhibiting tPA and uPA activities and thereby plasminogen activation and ECM degradation; (b) recruiting inflammatory cells to the sites and therefore increasing profibrogenic cytokines; and (c) suppressing the release of antifibrogenic growth factors from the sequestered sites on the ECM.